1PB-LSD & 1FE-LSD – Analysis of this new lysergamides

Explore Your Mind. Know Your Source.

That line isn’t marketing fluff — it’s the foundation of how we work at FairLSD.
Transparency, chemistry-first thinking, and responsible psychedelic culture guide every decision we make.

With the emergence of new legal lysergamides, one comparison keeps coming up: 1PB-LSD vs. 1FE-LSD.

This article lays out — clearly, calmly, and without hype — why 1PB-LSD is the more robust, better-understood, and chemically cleaner option.

What is a blotter — and why it matters

A blotter is a precisely dosed carrier paper infused with a defined amount of a lysergamide.
In this case: 250 µg of 1PB-LSD, produced with documented synthesis, analytical verification, and controlled handling.

For educational and laboratory contexts, blotters are ideal because they allow:

🔁 consistent sample sizes

🧪 reproducible analytical conditions

🗄️ long-term stability when stored correctly

Precision is not a luxury in chemistry — it’s a requirement.

Prodrugs explained (without the myths)

A prodrug is a molecule designed with a temporary protective group.
Only after a specific chemical or metabolic process is that group removed, revealing the core compound.

In lysergamide chemistry, this approach is well established. Known members of this family include:

Lysergamide N¹-acyl family

1PB-LSD fits squarely into this lineage — as a classic N¹-acyl prodrug, following known and well-characterized reaction pathways.

1PB-LSD vs. 1FE-LSD — the core difference

1FE-LSD: open questions remain

In online discussions, particularly on Reddit, concerns have been raised around the hydrolysis behavior and residual fragments of 1FE-LSD.

To be clear: we are not toxicologists, and definitive claims in either direction would be irresponsible.

What can be said is this:
the post-cleavage chemistry of 1FE-LSD is not yet fully transparent.

1PB-LSD: a familiar, predictable pathway

1PB-LSD behaves like a textbook N¹-acyl lysergamide prodrug.

Step-by-step (simplified):

→

Amidases and peptidases cleave the amide bond

→

The lysergamide core is released

→

The remaining substituent rapidly hydrolyzes further

Resulting breakdown products (from 250 µg 1PB-LSD):

~136 µg LSD (theoretical, analytical reference)

4-Hydroxybenzoic acid (~75 µg)

naturally occurring, widely present in food and parabens

Pinacol (~65 µg)

extremely low toxicity, metabolized to acetone

Boric acid (~6 µg elemental boron)

less boron than found in a fraction of a nut

· No exotic residues.

· No unknown side chains.

· No speculative toxicology required.

This is exactly why 1PB-LSD is favored from a chemical-clarity perspective.

Stability, storage, and analytical reliability

Early laboratory observations consistently indicate that 1PB-LSD outperforms older and less-defined analogues in several key areas:

higher molecular stability longer shelf life more consistent analytical results slightly extended analytical window predictable metabolism timing (≈ 2 hours)

Small structural refinements can make a big difference when reproducibility matters.

Molecular mass — putting numbers into context

· LSD: 323.43 g/mol

· 1PB-LSD: 603.37 g/mol

This means roughly 53.6 % of 1PB-LSD’s mass corresponds to the LSD core.

In analytical terms:

📏 250 µg of 1PB-LSD ≈ 137 µg LSD-equivalent
(assuming complete theoretical conversion under ideal conditions)

These figures are chemical reference values only — not pharmacological claims.

Why FairLSD chose 1PB-LSD

We didn’t choose 1PB-LSD because it’s new.

We chose it because it is:

chemically conservative, not experimental

structurally transparent

based on known enzymatic behavior

aligned with harm-reduction principles

consistent with responsible research culture

That philosophy is baked into everything we do.

Important notice

All FairLSD products are:

🚫 not intended for human consumption

🚫 not designed for in-vivo use

🔬 sold exclusively for educational, analytical, and laboratory purposes

We advocate knowledge, responsibility, and clarity — always.

Final thought

1PB-LSD isn’t louder, stronger, or more sensational.
It’s simply cleaner chemistry.

And in a space where trust matters, that’s the real upgrade.

Stay True. Be Free. Live Healthy.