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Everything about microdosing

- LSD Usage Advice

Hello Traveler, thank you for visiting this page!

Here you will get a brief introduction about the most important Information correlated to LSD and its usage. Please read through carefully – you will be definitely rewarded with important knowledge!

Even though we educate about LSD here, we clearly differentiate between the well-known drug LSD and the less researched research chemicals from the LSD substance group. 

All substances that we distribute on fairlsd.com are NOT suitable for consumption and are strictly available for research purposes. 

Due to the structural similarity to LSD, we still want to educate about LSD. 

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What is LSD?

LSD is a type of psychedelic substance. Such substances trigger changes in perception and thinking, often amplifying sensory awareness, yet reducing one's control over the experience.

What are the derivatives?

LSD derivatives refer to chemical compounds that are structurally similar to the classic psychedelic substance, LSD (Lysergic Acid Diethylamide). These analogs might exhibit similar properties to LSD due to their shared core structure, but they can possess unique characteristics due to variations in their molecular composition. Some known LSD analogs include 1P-LSD,1D-AL-LAD, 1D-LSD. However, these substances are strictly available for research purposes. 

Effects of using LSD:

LSD is a psychedelic hallucinogen. Psychedelic hallucinogens induce states of altered perception and thought, frequently with heightened awareness of sensory input but with diminished control over what is being experienced.

Table of Contents


The introduction aims to provide a basic understanding of the topic of microdosing. It is important to give the reader an overview of the topic and to highlight the relevance of the topic in the current scientific and social discussion.

Defenition of microdosing

Microdosing refers to the practice of taking extremely small amounts of psychoactive substances, usually about one-tenth of the usual dose known as a “trip”. This small amount is not intended to lead to hallucinogenic experiences, but to produce subtle yet remarkable changes in mood, perception and cognition.

In most cases, microdosing is done with psychedelics such as LSD or psilocybin. The idea is to benefit from the potential positive effects of these substances without going through the intense psychedelic experience. Users report increased creativity, improved mood, increased energy and other benefits.

Historical development

Although microdosing has gained a lot of popularity in recent years, especially in tech hubs like Silicon Valley, the practice has deeper historical roots. There is evidence that indigenous peoples in different parts of the world have used small amounts of psychoactive substances as part of their cultural or religious rituals.

In Western culture, microdosing came into focus in the 1960s and 1970s when substances such as LSD and psilocybin were intensively researched. Unfortunately, much of this research was interrupted due to legal and political obstacles.

The revival of interest in microdosing began in the 2010s, driven by a combination of anecdotal reports, popular science books and a general renaissance in psychedelic research. The tech and startup scene, particularly in California, played a key role in reviving interest in the practice, with many claiming that microdosing helped them increase their productivity and creativity.


The chapter on basics is intended to provide the reader with a solid background for understanding the mechanisms and concepts behind microdosing. Before diving into the specific forms, benefits and risks of microdosing, it is essential to lay the foundation for the discussion.

What are psychedelics?

Psychedelics are a class of substances that influence perception, mood and various cognitive processes. The term “psychedelic” comes from the Greek and means “revealing the mind”. These substances can produce a variety of experiences, from mild visual changes to profound spiritual or mystical experiences.

There are many different types of psychedelics, including but not limited to LSD, psilocybin, DMT and mescaline. While their chemical structures and specific effects may vary, they all share the ability to alter consciousness in ways that are often described as expansive.

Mode of action of psychedelics in low doses?

While the effects of full-dose psychedelics are well documented, the mode of action of microdoses is less clear. Microdosing is thought to have subperceptual effects, i.e. they are below the threshold of conscious awareness. This means that although someone who microdoses does not feel the typical “hallucinogenic” effects, there may still be changes in brain chemistry and function.

Some studies have suggested that microdosing may affect serotonin receptors in the brain, similar to higher doses of psychedelics but without the strong psychoactive effect. Other theories suggest that microdosing may improve neuronal connectivity and increase neuroplasticity, leading to increased creativity and problem-solving ability.

Placebo effect in the context of microdosing

An essential aspect of the discussion about microdosing is the possible influence of the placebo effect. The placebo effect occurs when a person experiences a change in their condition due to their expectations rather than the actual effect of a substance or treatment.

When studying microdosing, it is crucial to consider that some of the perceived benefits may be due to the placebo effect. Some studies have attempted to control for this by conducting placebo-controlled, double-blind trials in which neither the participants nor the researchers know who is receiving the real substance and who is receiving a placebo.

The basics chapter sets the stage for the deeper exploration of microdosing in the following chapters. It provides a general introduction to psychedelics and their effects, both in full doses and microdoses, and also highlights the importance of scientific control and critical thinking in this area.

-various forms of microdosing-

Microdosing has gained attention in recent years in various communities from the technology industry to psychological research. One reason for this is the variety of substances that can be used in microdoses. This chapter will focus on explaining the most common substances used in microdosing and examine their individual properties and effects.

LSD (Lysergic acid diethylamide)

LSD, one of the best-known psychedelics, is a popular choice for microdosing. It was discovered in the 1930s and became popular in both pop culture and scientific research in the 1960s.

  • Effect: In microdoses, LSD is said to increase creativity, focus and general zest for life without producing the typical hallucinogenic effects.
  • Dosage: A microdose of LSD is usually in the range of 5 to 20 micrograms, depending on individual tolerance and desired intensity.

Psilocybin (magic mushrooms)

Psilocybin is the active ingredient in over 200 species of mushrooms called “magic mushrooms” or “magic mushrooms”.

  • Effect: Users report that microdosing psilocybin can lead to increased empathy, improved well-being and increased creativity.
  • Dosage: A microdose of psilocybin is usually in the range of 0.1 to 0.3 grams of dried mushrooms, depending on the type and potency of the mushroom.

Ayahuasca (DMT in small quantities)

Ayahuasca is a brew from the Amazon region that contains DMT, a strong psychedelic agent.

  • Effect: In microdoses, ayahuasca can lead to increased mental clarity, better emotional processing and a stronger connection to nature.
  • Dosage: A microdose of ayahuasca varies greatly, as the potency of the brew varies depending on the preparation and ingredients.


Although cannabis is not traditionally considered a psychedelic, some people practice microdosing with cannabis, especially non-psychoactive CBD.

  • Effect: Microdosing of cannabis can lead to relaxation, pain relief and increased concentration without the typical “high” experience.
  • Dosage: Dosages vary depending on the THC and CBD content of the strain used and the method of consumption.


Ketamine is a dissociative anaesthetic used in medicine but also known for its psychedelic properties.

  • Effect: In microdoses, ketamine can help relieve depression and anxiety and increase general well-being.
  • Dosage: The exact dosage varies according to individual tolerance and desired effect. 

Other substances and combinations

There are many other substances that are less common but are used for microdosing in some communities. These include mescaline, ibogaine and certain RCs (research chemicals). Some users also experiment with combinations of substances to achieve synergistic effects.

This chapter provides a comprehensive overview of the different substances used in microdosing practice and offers detailed information on their individual effects, dosing recommendations and special considerations. It lays the foundation for a deeper understanding of the specific benefits and risks each substance brings.

-scientific findings-

In recent years, science has increasingly studied the phenomenon of microdosing. This chapter looks at the current scientific findings on the subject, from the cognitive and emotional effects to possible therapeutic applications.

Cognitive function and creativity

Microdosing is often touted as a means of enhancing cognitive abilities. Users report increased concentration, enhanced problem-solving abilities and creative thinking. Preliminary scientific studies support some of these claims, with most findings based on self-reports. The neurochemistry behind this may relate to increased synaptogenesis or other neuronal changes induced by psychedelic substances.

Mood and mental health

Microdosing is described by some users as a “natural antidepressant”. Some studies have shown a reduction in symptoms of depression and anxiety. This is thought to be through the modulation of serotonin receptors and the improvement of brain plasticity. However, further, more extensive studies are needed to confirm these findings.

Physiological effects and long-term consequences

Although microdosing is considered safe, the long-term physiological effects are still unclear. Some concerns relate to potential cardiovascular effects, especially with substances that affect serotonin receptors, as this can cause heart valve problems. It is also unclear whether there are long-term neurological or psychological consequences.

Limitations and criticisms of current research

Current research on microdosing is limited. Many studies are based on self-reports without placebo controls, which can lead to biased results. There are also ethical concerns about research with psychedelic substances, especially in countries where they are illegal.

Interactions with medicines and other substances

Taking psychedelic substances and other medicines at the same time can lead to interactions. For example, SSRI antidepressants might weaken the effect of psychedelic substances. It is important that people considering trying microdosing talk to a doctor first

Neuroplasticity and microdosing

Neuroplasticity refers to the brain’s ability to change over time. Some studies suggest that psychedelic substances, even in microdoses, can promote neuroplasticity, which could lead to improved learning and adaptive abilities.

ffects on specific population groups

Age, gender and other demographic factors could influence the response to microdosing. For example, hormonal differences between men and women could modulate the effects of psychedelic substances.

Tolerance development and microdosing

Tolerance refers to the need to take larger and larger doses of a substance to achieve the same effects. There are mixed reports on whether people develop tolerance to psychedelic substances when they are taken in microdoses.

Individual variability in the response to microdosing

Genetics, metabolic rate, diet and psychological state can influence the experience of microdosing. This means that two people taking the same dose of the same substance may have very different experiences.

Possible therapeutic applications

Beyond self-optimisation, there is growing interest in the therapeutic application of microdosing. Some preliminary studies and clinical reports suggest that microdosing may be useful for a range of conditions, including PTSD and OCD.

-Benefits of microdosing-

Microdosing of psychedelics has recently gained popularity, with many claiming it offers benefits for well-being and cognitive performance. This chapter highlights these potential benefits based on anecdotal reports and scientific studies. It is emphasised that research in this area is ongoing and further findings are expected.

Increasing productivity

Microdosing is often mentioned in connection with improved work performance and increased productivity. Many users report feeling more focused, energised and less easily distracted. Some also claim that they can complete more complex tasks faster and are better able to immerse themselves in a “flow” state – a state of complete immersion in a task. Scientific research in this area is limited, however, and many of the claims are based on anecdotal evidence.

Improving well-being

In addition to the cognitive benefits, many microdosing users report an overall increase in their well-being. This can take the form of improved mood, increased self-esteem and a more positive outlook on life. There are also reports of better stress management and emotional resilience. Some users describe feeling more connected to their surroundings, which can contribute to a sense of satisfaction.

Use in certain medical conditions

In addition to the general benefits, researchers are also investigating the therapeutic potential of microdosing for certain medical conditions. For example, there are reports and some preliminary studies suggesting that microdosing may help alleviate symptoms of certain conditions such as depression, anxiety and post-traumatic stress disorder (PTSD). Similarly, it is being discussed in relation to the treatment of ADHD and migraines. However, it is important to stress that despite promising reports, further controlled clinical trials are needed to confirm these claims and to understand how and why microdosing might work in these contexts.

The potential benefits of microdosing are certainly intriguing and are attracting both individuals and scientists. However, it is important to remember that while many of the benefits mentioned are based on anecdotal reports, scientific research in this area is still in its infancy. Therefore, caution is advised when relying on these reports or starting microdosing yourself.

-possible risks and side effects-

While microdosing offers many potential benefits, there are also concerns about possible risks and side effects. This chapter addresses the physical, psychological and legal challenges that may be associated with this practice. It is crucial to have a balanced understanding of microdosing that takes into account both the positive aspects and the potential dangers.

Physical risks

As with any substance introduced into the body, there are potential physical risks associated with microdosing. Some users have reported nausea, dizziness or sleep disturbances. There are also concerns about possible cardiovascular effects, as some psychedelic substances, especially those that affect the serotonin receptors, can cause heart valve problems. It is important to note that the physical effects of microdosing have not been extensively studied and many of the known risks are based on higher doses.

Improving well-being

Although many users report psychological benefits from microdosing, there are also potential psychological risks. These include increased anxiety, paranoia or the recurrence of traumatic memories. There is also a risk that people with a history of mental illness may experience undesirable changes in their mental state as a result of microdosing. Therefore, it is particularly important to consult a doctor or therapist before beginning a microdosing routine, especially if mental health problems already exist or have occurred in the past.

Legal considerations

The legal situation of psychedelic substances varies from country to country. In many countries, substances such as LSD or psilocybin are illegal, which means that microdosing with these substances would also be illegal. This poses risks related to law enforcement and possible legal consequences. Furthermore, the illegal status of these substances can lead to users obtaining substances of unknown quality and purity, which poses additional health risks.

The decision to microdose should not be taken lightly. While there are many anecdotal reports of the benefits, the potential risks and side effects are real. Interested parties should think carefully about the possible consequences, inform themselves thoroughly and seek medical advice before starting microdosing.

-Practical application and dosage-

Microdosing is not just a theoretical idea, but finds numerous supporters in practice. The right approach, the selection of the substance and the determination of the appropriate dose are crucial aspects. This chapter provides a detailed overview of the different dosing strategies, recommended protocols and practical advice to ensure that those interested take an informed and responsible approach to microdosing.

How to start microdosing?

Getting started with microdosing requires careful consideration and planning. It is advisable to do a lot of research beforehand and possibly consult with medical professionals or other experts. A clear plan of why you want to start microdosing and what your goals are is helpful. Keeping a diary of one’s experiences and observations during microdosing can also be beneficial to monitor the effects and possible side effects.

Dosage guide

The dosage guide for microdosing is crucial to achieve the desired benefits without unwanted side effects.

Standard microdosing

A generic small dose is often called a “standard microdose”. For LSD this is usually 10-20 micrograms, and for dried psilocybin mushrooms it is 0.2-0.5 grams. The idea behind standard dosing is to take an amount that is below the threshold of perception but still provides cognitive and emotional benefits.

Volumetric dosing

This method is particularly useful for substances that are difficult to divide into microdoses, such as LSD. It involves dissolving the psychedelic substance in a liquid (e.g. distilled water or alcohol) to allow for more accurate dosing. This technique allows the user to measure an exact dose and thus feel more confident in its use.

Dosage according to body weight

There is some evidence that the optimal dose of psychedelic substances varies with body weight. This method takes into account individual differences and may be particularly useful for people who are more sensitive to substances.

Justification and differences of dosing methods

Each method has its own rationale. While standard dosing is a generally accepted amount suitable for most people, volumetric dosing and dosing by body weight allow for a more individualised approach.

Microdosing protocols

The Fadiman Protocol

Named after the psychologist and author James Fadiman, one of the pioneers in modern psychedelic research. His protocol recommends taking a microdose every three days. This gives the body time to recover between doses and prevents the development of tolerance. Fadiman has collected hundreds of reports from people who have followed this protocol and many have reported positive results.

The Stamets Protocol

Paul Stamets, a renowned mycologist and advocate of mushroom therapies, suggests a more intensive protocol. He recommends dosing for five days and then taking a two-day break. Stamets believes that this routine can promote neurogenesis (growth of nerve cells).

Alternate protocol

This approach doses every other day, giving the body a day to recover. It offers a middle ground between the Fadiman and Stamets protocols.

Weekly protocol

Some users believe that a once-weekly dose is sufficient to get the benefits of microdosing without developing a tolerance.

-Ethics, culture and legal situation-

Microdosing touches not only individual experiences, but also cultural, ethical and legal dimensions. This chapter examines how different cultures and societies perceive microdosing and what ethical issues arise in connection with this practice. In addition, an overview of the legal situation of microdosing in different countries is given in order to create an understanding of the global implications and challenges.

Ethics of microdosing

Microdosing of psychedelic substances raises several ethical questions. First, there is the question of purpose: is microdosing used to enhance mental well-being and creativity, or is it used to cope with illness and disease? Is it ethically justifiable to enhance one’s cognitive abilities through the use of substances?

Another aspect is the potential abuse and overuse. Although microdosing is considered safer than traditional drug use, there is still a risk of addiction or overuse. It is ethical to recognise and respect the boundaries between use and abuse.

Cultural perspectives on microdosing

Different cultures have different relationships with psychedelic substances. In some indigenous communities, psychedelic plants have been used as sacraments or remedies for centuries. The modern practice of microdosing could be seen as an appropriation of these traditional practices if it is adopted without respect and understanding for their original cultural contexts.

On the other hand, many Western societies traditionally view psychedelic substances as illegal and dangerous. In this context, the interest in microdosing represents a challenge and possibly a shift in these views.

Legal situation in different countries

The legal situation around microdosing is complex and varies from country to country. In many countries, including the USA, substances such as LSD and psilocybin are illegal, regardless of the amount. This means that microdosing on these substances may be illegal, despite their potential benefits.

In some countries, however, there are signs that the laws are loosening, especially when it comes to medical or therapeutic uses. For example, some US states have begun to pass or amend laws to allow the medical use of psilocybin.

It is important to be aware of and respect local laws. Microdosing can have serious legal consequences depending on where you are.

-Conclusion and outlook-

Summary of the most important findings

After taking a comprehensive look at the phenomenon of microdosing, it becomes necessary to summarise the key insights and findings in a compact manner. The main findings include:

  • Definition and methodology: Microdosing refers to the consumption of sub-perceptual amounts of psychedelic substances to achieve specific benefits without experiencing the hallucinogenic effects.
  • Diversity of substances: Different substances such as LSD, psilocybin, ayahuasca and ketamine can be used for microdosing, each with its own properties and potential benefits.
  • Potential benefits and risks: Microdosing can offer cognitive and emotional benefits, including improved creativity, mood and focus. At the same time, there are risks and side effects to consider.
  • Scientific research: Although initial studies show promising results, further rigorous research is needed to validate the safety and efficacy of microdosing.

Potential for future research and applications

Looking at the current field of research, it is clear that the topic of microdosing is still at the beginning of its scientific exploration. There are many open questions that need to be further investigated:

  • Long-term effects: The effects of long-term microdosing on the body and mind are largely unknown. Future studies could focus on the potential long-term benefits and risks.
  • Therapeutic applications: The potential of microdosing to treat conditions such as depression, anxiety and PTSD is an exciting area of research.
  • Individualised dosing: How do individual differences such as genetics or metabolism influence responses to microdosing? This could lead to the development of personalised microdosing protocols.
  • Cultural and societal implications: How will microdosing affect society, especially in terms of ethics, legislation and culture?

To conclude this section, microdosing is a promising but under-researched field. It offers both opportunities and challenges and requires a thoughtful and critical approach to realise its full potential safely and responsibly.


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